AustralieFrV1, Main, Exploration, bibRecord, 008A19

Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis

Identifieur interne : 008A19 ( Main/Exploration ); précédent : 008A18; suivant : 008A20

Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis

Auteurs : P. Marquis [États-Unis] ; C. Roux [France] ; C. De La Loge [France] ; M. Diaz-Curiel [Espagne] ; C. Cormier [France] ; G. Isaia [Italie] ; J. Badurski [Pologne] ; J. Wark [Australie] ; P. J. Meunier [France]

Source :

Osteoporosis international [ 0937-941X ] ; 2008.

RBID : Pascal:08-0187121

Descripteurs français

Pascal (Inist)
- Ranélate de strontium, Prévention, Qualité de vie, Femme, Vertèbre, Ostéoporose, Fracture, Rhumatologie.
Wicri :
- topic : Femme.

English descriptors

KwdEn :
- Fracture, Osteoporosis, Prevention, Quality of life, Rheumatology, Strontium ranelate, Vertebra, Woman.

Abstract

Strontium ranelate reduces the risk of fracture in post-menopausal osteoporotic women with prevalent fractures for whom quality of life is severely impaired. The SOTI study, which used the SF-36® questionnaire and disease-specific QUALIOST® module, demonstrated that treatment with strontium ranelate improved osteoporotic women's quality of life compared with placebo. Introduction The Spinal Osteoporosis Therapeutic Intervention (SOTI) study demonstrated the effect of orally administered strontium ranelate versus placebo on the incidence of new vertebral fractures and compared impact on quality of life (QoL). Methods QoL was assessed 6 monthly over 3 years using the QUALIOST® and SF-36® questionnaires in post-menopausal osteoporotic women with prevalent fracture taking strontium ranelate or placebo 2 g/day. A total of 1,240 women were included (strontium ranelate: n=618 and placebo: n= 622). Results The QUALIOST® total score decreased in the strontium ranelate group, indicating preserved QoL compared with a deterioration in the placebo group (P=0.016). Strontium ranelate patients had reduced QUALIOST® emotional and physical dimension scores (P=0.019 and 0.032, respectively, versus placebo), indicating beneficial effects on emotional and physical functioning. There was a trend towards better SF-36® scores in the strontium ranelate group, although there were no significant between-group differences. More strontium ranelate patients (+ 31%) were free from back pain over 3 years versus placebo (P=0.005), with a significant effect from the first year of treatment (P= 0.023). Conclusion Strontium ranelate has beneficial effects on QoL in women with post-menopausal osteoporosis compared with placebo.

Affiliations:

Australie, Espagne, France, Italie, Pologne, États-Unis
Auvergne-Rhône-Alpes, Communauté de Madrid, Piémont, Rhône-Alpes, Île-de-France
Lyon, Madrid, Paris, Turin

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fracture</term>
<term>Osteoporosis</term>
<term>Prevention</term>
<term>Quality of life</term>
<term>Rheumatology</term>
<term>Strontium ranelate</term>
<term>Vertebra</term>
<term>Woman</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ranélate de strontium</term>
<term>Prévention</term>
<term>Qualité de vie</term>
<term>Femme</term>
<term>Vertèbre</term>
<term>Ostéoporose</term>
<term>Fracture</term>
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<front><div type="abstract" xml:lang="en">Strontium ranelate reduces the risk of fracture in post-menopausal osteoporotic women with prevalent fractures for whom quality of life is severely impaired. The SOTI study, which used the SF-36® questionnaire and disease-specific QUALIOST® module, demonstrated that treatment with strontium ranelate improved osteoporotic women's quality of life compared with placebo. Introduction The Spinal Osteoporosis Therapeutic Intervention (SOTI) study demonstrated the effect of orally administered strontium ranelate versus placebo on the incidence of new vertebral fractures and compared impact on quality of life (QoL). Methods QoL was assessed 6 monthly over 3 years using the QUALIOST® and SF-36® questionnaires in post-menopausal osteoporotic women with prevalent fracture taking strontium ranelate or placebo 2 g/day. A total of 1,240 women were included (strontium ranelate: n=618 and placebo: n= 622). Results The QUALIOST® total score decreased in the strontium ranelate group, indicating preserved QoL compared with a deterioration in the placebo group (P=0.016). Strontium ranelate patients had reduced QUALIOST® emotional and physical dimension scores (P=0.019 and 0.032, respectively, versus placebo), indicating beneficial effects on emotional and physical functioning. There was a trend towards better SF-36® scores in the strontium ranelate group, although there were no significant between-group differences. More strontium ranelate patients (+ 31%) were free from back pain over 3 years versus placebo (P=0.005), with a significant effect from the first year of treatment (P= 0.023). Conclusion Strontium ranelate has beneficial effects on QoL in women with post-menopausal osteoporosis compared with placebo.</div>
</front>
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Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis

Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri